(Benzo [4, 5] cyclohepta [l, 2??b] thiophen??4??ylidene) acetic Acids: Novel Non??ulcerogenic Antiinflammatory Agents

P Bollinger, P Cooper, HU Gubler…

文献索引：Bollinger; Cooper; Gubler; Leutwiler; Payne Helvetica Chimica Acta, 1990 , vol. 73, # 5 p. 1197 - 1204

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被引用次数: 13

摘要

Abstract Compound (Z)-8a has been found to display interesting antiinflammatory activity. In order to prepare derivatives with a wide variety of substituents in the aromatic part of the molecule, a new synthesis of the key intermediates 9a-g was developed starting from thiophene-3-carboxylic acid (11) and substituted benzyl bromides. The conversion of 9a-g to 10a-g follows a known procedure. Ketones 10a-g, on reaction with alkyl (dialkoxy- ...