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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Potential antitumor agents. Part 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent

GJ Atwell, BF Cain, BC Baguley, GJ Finlay…

文献索引：Atwell; Cain; Baguley; Finlay; Denny Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1481 - 1485

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被引用次数: 129

摘要

The synthesis and biological activities of representatives of a new class of antitumor agent, the N-[2-(dialkyl-amino) ethyl]-9-aminoacridine-4-carboxamides, are reported. Members of this class are stable and very water soluble with high levels of in vitro and in vivo antitumor activity. The compounds bind tightly to double-stranded DNA by intercalation, but the requirements for antitumor activity are more restrictive. They depend critically on the ...

4-羧基-9-茚酮结构式

4-羧基-9-茚酮

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9-Amino-N-(2-((2-hydroxyethyl)amino)ethyl)-4-acridinecarboxamide结构式

9-Amino-N-(2-((...

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9-chloroacridine-4-carbonyl chloride结构式

9-chloroacridin...

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9-Amino-N-(2-((2-hydroxyethyl)amino)ethyl)-4-acridinecarboxamide结构式

9-Amino-N-(2-((...

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2,2′-亚氨基二苯甲酸结构式

2,2′-亚氨基二苯甲酸

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9-Amino-N-(2-((2-hydroxyethyl)amino)ethyl)-4-acridinecarboxamide结构式

9-Amino-N-(2-((...

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4-羧基-9-茚酮结构式

4-羧基-9-茚酮

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9-chloro-N-(2-morpholin-4-ylethyl)acridine-4-carboxamide结构式

9-chloro-N-(2-m...

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2,2′-亚氨基二苯甲酸结构式

2,2′-亚氨基二苯甲酸

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9-chloro-N-(2-morpholin-4-ylethyl)acridine-4-carboxamide结构式

9-chloro-N-(2-m...

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4-羧基-9-茚酮结构式

4-羧基-9-茚酮

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9-Amino-N-(5-(dimethylamino)pentyl)-4-acridinecarboxamide结构式

9-Amino-N-(5-(d...

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9-chloroacridine-4-carbonyl chloride结构式

9-chloroacridin...

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9-Amino-N-(5-(dimethylamino)pentyl)-4-acridinecarboxamide结构式

9-Amino-N-(5-(d...

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N-[2-(dimethylamino)ethyl]-9-phenoxyacridine-4-carboxamide结构式

N-[2-(dimethyla...

氨基甲烷结构式

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N-[2-(dimethylamino)ethyl]-9-(methylamino)acridine-4-carboxamide结构式

N-[2-(dimethyla...

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2,2′-亚氨基二苯甲酸结构式

2,2′-亚氨基二苯甲酸

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9-Amino-N-(5-(dimethylamino)pentyl)-4-acridinecarboxamide结构式

9-Amino-N-(5-(d...

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4-羧基-9-茚酮结构式

4-羧基-9-茚酮

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9-Amino-N-(6-(dimethylamino)hexyl)-4-acridinecarboxamide结构式

9-Amino-N-(6-(d...

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9-chloroacridine-4-carbonyl chloride结构式

9-chloroacridin...

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9-Amino-N-(6-(dimethylamino)hexyl)-4-acridinecarboxamide结构式

9-Amino-N-(6-(d...

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2,2′-亚氨基二苯甲酸结构式

2,2′-亚氨基二苯甲酸

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9-Amino-N-(6-(dimethylamino)hexyl)-4-acridinecarboxamide结构式

9-Amino-N-(6-(d...

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对硝基苯酚结构式

对硝基苯酚

4-羧基-9-茚酮结构式

4-羧基-9-茚酮

~74%

(4-nitrophenyl) 9-oxo-10H-acridine-4-carboxylate结构式

(4-nitrophenyl)...

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2,2′-亚氨基二苯甲酸结构式

2,2′-亚氨基二苯甲酸

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(4-nitrophenyl) 9-oxo-10H-acridine-4-carboxylate结构式

(4-nitrophenyl)...

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(4-nitrophenyl) 9-oxo-10H-acridine-4-carboxylate结构式

(4-nitrophenyl)...

~80%

(4-nitrophenyl) 9-chloroacridine-4-carboxylate结构式

(4-nitrophenyl)...

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4-羧基-9-茚酮结构式

4-羧基-9-茚酮

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(4-nitrophenyl) 9-chloroacridine-4-carboxylate结构式

(4-nitrophenyl)...

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2,2′-亚氨基二苯甲酸结构式

2,2′-亚氨基二苯甲酸

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(4-nitrophenyl) 9-chloroacridine-4-carboxylate结构式

(4-nitrophenyl)...

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9-chloroacridine-4-carbonyl chloride结构式

9-chloroacridin...

N,N-二甲基乙二胺结构式

N,N-二甲基乙二胺

~73%

9-chloro-N-[2-(dimethylamino)ethyl]acridine-4-carboxamide结构式

9-chloro-N-[2-(...

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2,2′-亚氨基二苯甲酸结构式

2,2′-亚氨基二苯甲酸

~%

9-chloro-N-[2-(dimethylamino)ethyl]acridine-4-carboxamide结构式

9-chloro-N-[2-(...

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4-羧基-9-茚酮结构式

4-羧基-9-茚酮

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N-[2-(dimethylamino)ethyl]-9-phenoxyacridine-4-carboxamide结构式

N-[2-(dimethyla...

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2,2′-亚氨基二苯甲酸结构式

2,2′-亚氨基二苯甲酸

~%

N-[2-(dimethylamino)ethyl]-9-phenoxyacridine-4-carboxamide结构式

N-[2-(dimethyla...

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4-羧基-9-茚酮结构式

4-羧基-9-茚酮

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9-Amino-N-(3-(dimethylamino)propyl)-4-acridinecarboxamide结构式

9-Amino-N-(3-(d...

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9-chloroacridine-4-carbonyl chloride结构式

9-chloroacridin...

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9-Amino-N-(3-(dimethylamino)propyl)-4-acridinecarboxamide结构式

9-Amino-N-(3-(d...

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2,2′-亚氨基二苯甲酸结构式

2,2′-亚氨基二苯甲酸

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9-Amino-N-(3-(dimethylamino)propyl)-4-acridinecarboxamide结构式

9-Amino-N-(3-(d...

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9-chloro-N-(3-(dimethylamino)propyl)acridine-4-carboxamide结构式

9-chloro-N-(3-(...

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9-Amino-N-(3-(dimethylamino)propyl)-4-acridinecarboxamide结构式

9-Amino-N-(3-(d...

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4-羧基-9-茚酮结构式

4-羧基-9-茚酮

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9-amino-N-(2-aminoethyl)acridine-4-carboxamide结构式

9-amino-N-(2-am...

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9-chloroacridine-4-carbonyl chloride结构式

9-chloroacridin...

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9-amino-N-(2-aminoethyl)acridine-4-carboxamide结构式

9-amino-N-(2-am...

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2,2′-亚氨基二苯甲酸结构式

2,2′-亚氨基二苯甲酸

~%

9-amino-N-(2-aminoethyl)acridine-4-carboxamide结构式

9-amino-N-(2-am...

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4-羧基-9-茚酮结构式

4-羧基-9-茚酮

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9-氨基-N-(2-吗啉-4-基乙基)吖啶-4-羧酰胺结构式

9-氨基-N-(2-吗啉-4-...

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2,2′-亚氨基二苯甲酸结构式

2,2′-亚氨基二苯甲酸

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9-氨基-N-(2-吗啉-4-基乙基)吖啶-4-羧酰胺结构式

9-氨基-N-(2-吗啉-4-...

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9-chloroacridine-4-carbonyl chloride结构式

9-chloroacridin...

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N-[2-(dimethylamino)ethyl]-9-phenoxyacridine-4-carboxamide结构式

N-[2-(dimethyla...

查看详情