Further Definition of the D1 Dopamine Receptor Pharmacophore: Synthesis of trans-6, 6a, 7, 8, 9, 13b-Hexahydro-5 H-benzo [d] naphth [2, 1-b] azepines as Rigid …

…, DE Nichols, VJ Watts, RB Mailman

文献索引：Negash; Nichols; Watts; Mailman Journal of medicinal chemistry, 1997 , vol. 40, # 14 p. 2140 - 2147

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被引用次数: 12

摘要

In an effort to define further the active geometry of the β-phenyldopamine pharmacophore of certain dopamine D1 agonists, the title compounds have been synthesized as conformationally restricted homologues of the potent benzophenanthridine dopamine D1 agonist dihydrexidine 4a. The dihydroxy secondary amine 5b was evaluated as a potential agonist, whereas the N-methyl compounds 5a and 5c were hypothesized to be ...