Tetrahedron

Preparation of 6-aminoquinazolin-4 (3H)-ones via direct SN Ar on the quinazoline ring

B Barlaam, CS Harris, J Lecoq, HTH Nguyen

文献索引：Barlaam, Bernard; Harris, Craig S.; Lecoq, Jonathan; Nguyen, Ha Thi Hoang Tetrahedron, 2012 , vol. 68, # 2 p. 534 - 543

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被引用次数: 6

摘要

The preparation of 6-aminoquinazolin-4 (3H)-ones requires the use of platinum–metal group catalysis on the corresponding C-6-iodo or 6-bromo precursors. Herein, we report to our knowledge the first successful SNAr reaction directly at the unactivated C-6 position of the quinazolin-4 (3H)-one nucleus.