Abstract In an effort to design new hybrid compounds with dual properties, ie binding affinity at histamine H 3 receptors and inhibitory potency at the catabolic enzyme histamine N τ- methyltransferase (HMT), a novel series of 1-substituted piperidine derivatives was synthesized. This alicyclic heterocycle is structurally linked via aminoalkyl spacers of variable lengths to additional aromatic carbo-or hetero-cycles. These new hybrid drugs ...
