Novel tetrahydroisoquinolines are histamine H 3 antagonists and serotonin reuptake inhibitors

…, JM Miller, AJ Barbier, P Bonaventure, JD Boggs…

文献索引：Letavic, Michael A.; Keith, John M.; Jablonowski, Jill A.; Stocking, Emily M.; Gomez, Leslie A.; Ly, Kiev S.; Miller, Jennifer M.; Barbier, Ann J.; Bonaventure, Pascal; Boggs, Jamin D.; Wilson, Sandy J.; Miller, Kirsten L.; Lord, Brian; McAllister, Heather M.; Tognarelli; Wu, Jiejun; Abad, Marta C.; Schubert, Carsten; Lovenberg, Timothy W.; Carruthers, Nicholas I. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 1047 - 1051

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被引用次数: 35

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of novel 4-aryl-1,2,3,4-tetrahydroisoquinoline-based histamine H 3 ligands that also have serotonin reuptake transporter inhibitor activity is described. The synthesis, in vitro biological data, and select pharmacokinetic data for these novel compounds are discussed.