A solvent-free synthesis of coumarins using a Wells–Dawson heteropolyacid as catalyst

GP Romanelli, D Bennardi, DM Ruiz, G Baronetti…

文献索引：Romanelli; Bennardi; Ruiz; Baronetti; Thomas; Autino Tetrahedron Letters, 2004 , vol. 45, # 48 p. 8935 - 8939

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被引用次数: 121

摘要

Substituted coumarins are synthesized from phenols and β-ketoesters by the Pechmann reaction, using a Wells–Dawson heteropolyacid (H6P2W18O62· 24H2O) as catalyst by a solvent-free procedure. This one requires low reaction times, 130° C temperature and as little as 1mol% of Wells–Dawson acid, obtaining good to excellent yields of coumarins. The catalyst showed to be reusable with no differences in the yields. The results are compared ...