Synthesis and biological activities of the marine bryozoan alkaloids convolutamines A, C and F, and lutamides A and C

H Hashima, M Hayashi, Y Kamano, N Sato

文献索引：Hashima, Hirofumi; Hayashi, Masahiko; Kamano, Yoshiaki; Sato, Nobuhiro Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 7 p. 1757 - 1766

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被引用次数: 25

摘要

Synthesis of convolutamines and lutamides, new 2, 4, 6-tribromo-3-methoxyphenethylamine alkaloids isolated from Floridian marine bryozoan Amathia convoluta, was accomplished by a sequence of reactions starting from 3-hydroxyphenethylamines. Cytotoxities of the synthetic lutamides, convolutamines and their de-O-methyl derivatives were examined using drug-sensitive and-resistant P388 as well as KB cell lines. The bioassay suggests that the ...