Discovery of 5-HT 6 receptor ligands based on virtual HTS

…, E Cubero, R Pascual, JR Quintana-Ruiz…

文献索引：Tasler, Stefan; Kraus, Juergen; Wuzik, Andreas; Mueller, Oliver; Aschenbrenner, Andrea; Cubero, Elena; Pascual, Rosalia; Quintana-Ruiz, Jordi-Ramon; Dordal, Alberto; Merce, Ramon; Codony, Xavier Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 22 p. 6224 - 6229

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被引用次数: 6

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Based on a pharmacophore alignment on a 5-HT 6 ligand applying 4SCan ® technology, a new lead series was identified and further structurally investigated. K i s down to 8 nM were achieved. ... The discovery and SAR studies of 5-HT 6 ligands are described. ... As crystal structure data ...