Synthesis and evaluation of novel spermidine derivatives as targeted cancer chemotherapeutic agents

…, GG Meadows, MM Abdel-Monem

文献索引：Stark, Peter A.; Thrall, Brian D.; Meadows, Gary G.; Abdel-Monem, Mahmoud M. Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4264 - 4269

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被引用次数: 40

摘要

The utility of the spermidine moiety as the homing device for the selective delivery of chemotherapeutic and diagnostic agents into cancer cells was explored. Two spermidine analogs containing a cytotoxic agent were synthesized, N-[3, 4-bis (benzyloxy) phenethyl]- Na-(3-amino-propyl)-L-ornithinamide trihydrochloride, la and N-[4-[bis (2-chloroethyl) amino] phenethyl]-Nu-(3-aminopropyl)-~-ornithinamide tetrahydrochloride, l b. These compounds ...