Synthesis of [2??(Trimethylsilyl) ethynyl] pyrazoles Based on Bis (trimethylsilyl) acetylene and Arylacetyl Chlorides

AS Pankova, PR Golubev, IV Ananyev…

文献索引：Pankova, Alena S.; Golubev, Pavel R.; Kuznetsov, Mikhail A.; Ananyev, Ivan V. European Journal of Organic Chemistry, 2012 , # 30 p. 5965 - 5971,7

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被引用次数: 4

摘要

Abstract A practical approach to the synthesis of [2-(trimethylsilyl) ethynyl] pyrazoles was developed through condensation of hydrazines with enynones that are easily accessible frombis (trimethylsilyl) acetylene and arylacetyl chlorides. Optimized conditions for reactions with monoarylhydrazines permit the chemoselective formation of 5-alkynylpyrazoles in high yields (48–94%). When monoalkylhydrazines or the parent hydrazine is used, mixtures of ...