Patent Update Biologicals & Immunologicals: DNA topoisomerase inhibitors: potential uses in molecular medicine

AK Chakraborty, HK Majumder…

文献索引：US4840954 A1, ;

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摘要

... 0 26 novobiocin: X = CH3; Y = NH2 27 chlorobiocin: X = CI; Y = 2-methyl-pyrrol-5-yl Coumarin antibiotics are also potent gyrase inhibitors. Novobiocin, chlorobiocin, and coumerrnycin A1 in- hibit the gyrase B subunit function (ATPase activity) at very low concentrations [21. ...