Potential antitussives: Synthesis and pharmacology of a series of 1-[2-amino-2-(4-fluorophenyl) ethyl]-4-(2-benzoylpropyl) piperazines

Z Vejdělek, M Protiva

文献索引：Vejdelek; Protiva Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 10 p. 2977 - 2988

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被引用次数: 1

摘要

Abstract Compound V, obtained by a reaction of 2-chloro-4'-fluoroacetophenone with 1- (ethoxycarbonyl) piperazine, was reduced with sodium borohydride to the amino alcohol VIf. The hydrochloride of VIf was treated with thionyl chloride to give the hydrochloride of 1-[2- chloro-2-(4-fluorophenyl) ethyl]-4-(ethoxycarbonyl) piperazine (VIg). The crude VIg was subjected to substitution reactions with diethylamine, pyrrolidine, piperidine, morpholine ...