Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: Modifications of the oxazolidinone ring leading to the discovery of anacetrapib

CJ Smith, A Ali, ML Hammond, H Li, Z Lu…

文献索引：Journal of Medicinal Chemistry, , vol. 54, # 13 p. 4880 - 4895

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被引用次数: 31

摘要

... Journal of Medicinal ... recent results from the phase III safety study DEFINE, have thus far given no evidence of blood pressure or aldosterone increases and so development of the compound continues.(33, 50, 51) Herein we describe the medicinal chemistry that led to ... Chemistry. ...