Paclitaxel (1, Taxol), [2] by virtue of its complex and densely functionalised structure, coupled with its novel mechanism of action, potent antitumor activity and its clinical use as a powerful anti-cancer drug has attracted the attention of many synthetic chemists. Indeed, only very few molecules in the last two decades have stirred as much imagination and activity among synthetic chemists as taxanes. [3] While a few paid attentions to the total synthesis of 1, a large ...
