Pyrido [2, 1-b] quinazolinecarboxamide derivatives as platelet activating factor antagonists

…, C Burghardt, TF Mowles, FJ Leinweber…

文献索引：Tilley, Jefferson W.; Burghardt, Barbara; Burghardt, Charles; Mowles, Thomas F.; Leinweber, Franz-Josef; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 466 - 472

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被引用次数: 10

摘要

A series of N-[(heteroaryl) alkyl] pyrido [2, 1-b] quinazolines were evaluated for their ability to inhibit the binding of radiolabeled platelet activating factor (PAF) to its receptor on dog platelets. The most potent compounds in this series were found to be pyrido [2, 1-b] quinazoline-8-carboxamides possessing a four-or six-carbon chain between the carboxamide nitrogen atom and a 3-pyridinyl or 5-pyrimidinyl moiety. Since earlier ...