Studies on Potential Antiviral Compounds, XXIII. 2??(Substituted benzoylamino)??3, 5??dichloropyridines and isosteric benzamides

…, G Giovanninetti, M Borgatti, AM Bartoletti

文献索引：Ferranti; Garuti; Giovanninetti; Borgatti; Bartoletti Archiv der Pharmazie, 1985 , vol. 318, # 1 p. 78 - 84

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被引用次数: 6

摘要

Abstract Novel 2-(substituted benzoylamino)-3, 5-dichloropyridines and isosteric benzamides were synthesized and tested in vitro against the MP strain of herpes simplex virus type 1 [HSV-1 (MP)]. The introduction of methoxy groups at the 2-and 6-positions of the benzoyl moiety yielded compounds which significantly inhibit HSV-1 (MP) growth. Substitution with fluorine at the 4-position of the benzoyl group resulted in inactive ...