Xenobiotica

Identification of human cytochrome P450 isoforms involved in the metabolism of brotizolam

…, W Kishimoto, K Sakai, A Nagakura, T IGARASHI*

文献索引：Senda; Kishimoto; Sakai; Nagakura; Igarashi Xenobiotica, 1997 , vol. 27, # 9 p. 913 - 922

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被引用次数: 21

摘要

1. To identify the cytochrome P450 (CYP) isoenzyme (s) responsible for the major metabolic pathways of brotizolam in man, we examined the metabolism of brotizolam using human liver microsomes and microsomes expressing individual human CYP isoenzymes (CYP1A1, 1A2, 2A6, 2B6, 2C9, 2C19, 2D6, 2E1, 3A4). 2. Brotizolam was metabolized to α-OH-and 6- OH-brotizolam by human liver microsomes (n= 3). V max for α-and 6-hydroxylation of ...