Using the catalytic asymmetric Sharpless carbamate aminohydroxylation, conformationally restricted l-arginine and l-homoarginine derivatives (5-8) were prepared in good enantiomeric excess to investigate the binding requirements of l-arginine-based compounds with nitric oxide synthase. The l-arginine derivatives (5 and 6) inhibited both the inducible and neuronal isoforms of nitric oxide synthase with little isoform selectivity (5, IC50= 42 ...
