Abstract A convergent and streamlined synthesis of selective vascular endothelial growth factor receptor (VEGFR) 2 kinase inhibitors has been achieved using a synthetic strategy based on an SN Ar reaction of 6-chloroimidazo [1, 2-b] pyridazine with phenols in the final step. For the synthesis of 6-chloroimidazo [1, 2-b] pyridazine, a one-pot reaction using 3- amino-6-chloropyridazine, cyclopropanecarboxamide, and bromoacetyl bromide was ...
