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Cobalt-catalyzed cocyclizations of isocyanato alkynes: a regiocontrolled entry into 5-indolizinones. Application to the total synthesis of camptothecin

RA Earl, KPC Vollhardt

文献索引:Earl; Vollhardt Journal of the American Chemical Society, 1983 , vol. 105, # 23 p. 6991 - 6993

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被引用次数: 57

摘要

T= Thymine modified histone peak corresponding to 2 gave a pure product whose chromatographic behavi~ rs,~~ J~ UV~ pectrum,'~ and 400-MHz'H NMR8 are identical with those of the authentic sample obtained from the model experiment. The contents of thymine- lysine adduct 2 were directly determined by HPLC analysis of the acid hydrolysates of UV- irradiated nucleohistone under various conditions. The amount of 2 in UV-irradiated ...