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Syntheses of hydroxy ketones from lactones

…, D Savoia, C Trombini, A Umani-Ronchi

文献索引:Cavicchioli, Silvia; Savoia, Diego; Trombini, Claudio; Umani-Ronchi, Achille Journal of Organic Chemistry, 1984 , vol. 49, # 7 p. 1246 - 1251

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被引用次数: 36

摘要

y-Hydroxy ketones (4, n= 2) are cleanly obtained by the addition of 1.1 equiv of n- butyllithium to y-lactones dissolved in ether at-90" C, since in these conditions the formation of diols by double organometallic attack is avoided, especially in the case of substituted lactones. The corresponding reactions performed in tetrahydrofuran are less satisfactory. The method cannot be applied to 6-valerolactone and to t-caprolactone, as well as to p- ...

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