Journal of the American Chemical Society

Resolution of binaphthols and spirobiindanols using cholesterol esterase

RJ Kazlauskas

文献索引：Kazlauskas, Romas J. Journal of the American Chemical Society, 1989 , vol. 111, # 13 p. 4953 - 4959

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被引用次数: 141

摘要

Abstract: Cholesterol esterase (EC 3.1. 1.13) catalyzes the hydrolysis of steroid, binaphthol, and spirobiindanol esters. The hydrolysis of binaphthol and spirobiindanol esters is enantiospecific and can be used to resolve these materials. Simple, synthetic-scale (200 g) procedures are detailed for the resolution of [l, l'-binaphthalene]-2, 2'-diol (1) and 2, 2', 3, 3'- tetra-hydro-3, 3, 3', 3'-tetramethyl-l, l'-spirobi [IH-indene]-6, 6'-diol (6). Resolution of 1 ...