Amidines. 4. Synthesis of Tricyclic Guanidines Journal of Medicinal Chemistry, 1973, Vol. 16, No. 4 407 tained a further 0.5 g for a total yield of 91% of 37. A sample recrystallized from MeOH-Et, O melted at 139-140". Anal.(C,, H,, Br, OS). Conversion of Sulfonium Salt 37 to the Corresponding Tetrahydrofurfuryl Bromide (38). The sulfonium salt 37, 6.6 g (15 mmol), was heated at 160"(12 mm) for 30 min and then distilled at 158-162'(0.02 mm) to yield 4.35 g ( ...
