A photoswitchable ITAM peptidomimetic: Synthesis and real time surface plasmon resonance (SPR) analysis of the effects of cis–trans isomerization on binding

…, LTM van Wandelen, J Nico, RMJ Liskamp

文献索引：Kuil, Joeri; van Wandelen, Loek T.M.; de Mol, Nico J.; Liskamp, Rob M.J. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 3 p. 1393 - 1399

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被引用次数: 15

摘要

The Syk protein plays an important role in immune receptor signaling. The Syk tandem SH2 domain (tSH2)–ITAM interaction is important for recruiting Syk to the receptor complex and for Syk kinase activation. A peptidomimetic ligand for tSH2 was synthesized in which a photoswitchable azobenzene moiety was incorporated. Such a photoswitchable moiety may regulate the distance between the two phosphotyrosine containing ITAM sequences, ...