Tetrahedron

Practical synthesis of S-alkyl thiocarbamate herbicides by carbonylation of amines with carbon monoxide and sulfur

T Mizuno, T Iwai, T Ito

文献索引：Mizuno, Takumi; Iwai, Toshiyuki; Ito, Takatoshi Tetrahedron, 2004 , vol. 60, # 12 p. 2869 - 2873

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被引用次数: 23

摘要

An industrial and economic carbonylation of amines with carbon monoxide and sulfur has been developed for the synthesis of S-alkyl thiocarbamate herbicides. In the presence of potassium carbonate and solvent DMSO, S-alkyl thiocarbamates, such as thiobencarb and orbencarb (herbicides) are synthesized in excellent yields from amines, carbon monoxide, sulfur, and alkyl halides under mild conditions (1atm, 20° C).