Synthesis of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetate, a hypolipidemic agent, and related compounds

T Moriya, M Seki, S Takabe, K Matsumoto…

文献索引：Moriya; Seki; Takabe; Matsumoto; Takashima; Mori; Odawara; Takeyama Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1197 - 1204

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被引用次数: 13

摘要

The a-alkyl homologues (69-72) of ethyl 5-furyl-4-oxazoleacetates (35 and 45) were easily prepared by mono-and di-a-alkylation on the active methylene group of the oxazoleacetic acid moiety with use of usual metallic bases such as sodium hydride as illustrated in Scheme 11. The esters obtained were hydrolyzed to the corresponding acids (73 and 74).