Synthesis and reaction of 5??amino??3??trifluoromethylisoxazole and??pyrazole??4??carboxylic acids

…, T Suzuki, S Maeno, K Mitsuhashi

文献索引：Tanaka, Kiyoshi; Suzuki, Takashi; Maeno, Seiji; Mitsuhashi, Keiryo Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 1535 - 1538

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被引用次数: 26

摘要

Abstract 5-Amino-3-trifluoromethylisoxazole-and-pyrazole-4-carboxylic acids were prepared by the reactions ot trifluoroacetonitrile oxide or-imines with cyanoacetic acid derivatives, respectively. The behavior of thus obtained aminoazole-4-carboxylic acids toward some electrophiles was examined. In acylation with acyl chlorides, the aminoisoxazole-4- carboxylate 2a was diacylated to give the (diacylamino) isoxazole-4-carboxylate 7, ...