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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Imdazole systems. I. Imidzo [2, 1??b][1, 3, 5] benzothiadiazepine derivatives as potential antipsychotic agents

LD Vecchia, J Dellureficio, B Kisis…

文献索引：Della Vecchia; Dellureficio; Kisis; Vlattas Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 5 p. 1287 - 1294

全文：HTML全文

被引用次数: 7

摘要

Abstract Imidazo [2, 1-b][1, 3, 5] benzothiadiazepine 3 constitutes a novel ring system, and its analogs 3a-i were synthesized to investigate their potential antipsychotic activity. The synthesis of the ring system was achieved by reaction of 2-aminophenylthioimidazoles 7 with phosgene or thiophosgene and by ring closure of the 1-[2-(2-imidazolyl) thiophenyliminocarbonyl]-1-piperazines 13. An efficient method for the conversion of ...

2-巯基-4-甲基咪唑结构式

2-巯基-4-甲基咪唑

邻氯硝基苯结构式

邻氯硝基苯

~81%

5-methyl-2-(2-nitrophenyl)sulfanyl-1H-imidazole结构式

5-methyl-2-(2-n...

2-(4-chloro-2-nitrophenyl)sulfanyl-1H-imidazole结构式

2-(4-chloro-2-n...

~80%

5-chloro-2-(1H-imidazol-2-ylsulfanyl)aniline结构式

5-chloro-2-(1H-...

邻溴硝基苯结构式

邻溴硝基苯

2-巯基咪唑结构式

~84%

2-(2-nitrophenyl)sulfanyl-1H-imidazole结构式

2-(2-nitropheny...

2-(2-nitrophenyl)sulfanyl-1H-imidazole结构式

2-(2-nitropheny...

~84%

2-(1H-imidazol-2-ylsulfanyl)aniline结构式

2-(1H-imidazol-...

邻溴硝基苯结构式

邻溴硝基苯

~%

2-(1H-imidazol-2-ylsulfanyl)aniline结构式

2-(1H-imidazol-...

N-甲基哌嗪结构式

5-methylthioimidazo[2,1-b][1,3,5]benzothiadiazepine结构式

5-methylthioimi...

~55%

喷硫平结构式

邻溴硝基苯结构式

邻溴硝基苯

~%

喷硫平结构式

2-(1H-imidazol-2-ylsulfanyl)aniline结构式

2-(1H-imidazol-...

~%

喷硫平结构式

2-(2-nitrophenyl)sulfanyl-1H-imidazole结构式

2-(2-nitropheny...

~%

喷硫平结构式

imidazo[2,1-b][1,3,5]benzothiadiazepine-5(6H)-thione结构式

imidazo[2,1-b][...

~%

喷硫平结构式

N-甲基哌嗪结构式

~%

喷硫平结构式

imidazo[2,1-b][1,3,5]benzothiadiazepine-5(6H)-one结构式

imidazo[2,1-b][...

~%

喷硫平结构式

溴化氰结构式

1-[2-(2-imidazolyl)thiophenyliminothiocarbonyl]-4-methylpiperazine结构式

1-[2-(2-imidazo...

~%

喷硫平结构式

N-[2-(1H-imidazol-2-ylsulfanyl)phenyl]-4-methylpiperazine-1-carboxamide结构式

N-[2-(1H-imidaz...

~%

喷硫平结构式

N-甲基哌嗪结构式

5-cyanothioimidazo[2,1-b][1,3,5]benzothiadiazepine结构式

5-cyanothioimid...

~%

喷硫平结构式

2,5-二氯硝基苯结构式

2,5-二氯硝基苯

~%

5-chloro-2-(1H-imidazol-2-ylsulfanyl)aniline结构式

5-chloro-2-(1H-...

N-甲基哌嗪结构式

imidazo[2,1-b][1,3,5]benzothiadiazepine-5(6H)-one结构式

imidazo[2,1-b][...

~98%

N-[2-(1H-imidazol-2-ylsulfanyl)phenyl]-4-methylpiperazine-1-carboxamide结构式

N-[2-(1H-imidaz...

邻溴硝基苯结构式

邻溴硝基苯

~%

N-[2-(1H-imidazol-2-ylsulfanyl)phenyl]-4-methylpiperazine-1-carboxamide结构式

N-[2-(1H-imidaz...

2-(1H-imidazol-2-ylsulfanyl)aniline结构式

2-(1H-imidazol-...

~%

N-[2-(1H-imidazol-2-ylsulfanyl)phenyl]-4-methylpiperazine-1-carboxamide结构式

N-[2-(1H-imidaz...

2-(2-nitrophenyl)sulfanyl-1H-imidazole结构式

2-(2-nitropheny...

~%

N-[2-(1H-imidazol-2-ylsulfanyl)phenyl]-4-methylpiperazine-1-carboxamide结构式

N-[2-(1H-imidaz...

2-(4-fluoro-2-nitrophenyl)sulfanyl-1H-imidazole结构式

2-(4-fluoro-2-n...

~82%

5-fluoro-2-(1H-imidazol-2-ylsulfanyl)aniline结构式

5-fluoro-2-(1H-...

2,5-二氟硝基苯结构式

2,5-二氟硝基苯

~%

5-fluoro-2-(1H-imidazol-2-ylsulfanyl)aniline结构式

5-fluoro-2-(1H-...

2-[2-nitro-4-(trifluoromethyl)phenyl]sulfanyl-1H-imidazole结构式

2-[2-nitro-4-(t...

~85%

2-(1H-imidazol-2-ylsulfanyl)-5-(trifluoromethyl)aniline结构式

2-(1H-imidazol-...

4-氯-3-硝基三氟甲苯结构式

4-氯-3-硝基三氟甲苯

~%

2-(1H-imidazol-2-ylsulfanyl)-5-(trifluoromethyl)aniline结构式

2-(1H-imidazol-...

2-(4-methoxy-2-nitrophenyl)sulfanyl-1H-imidazole结构式

2-(4-methoxy-2-...

~92%

2-(1H-imidazol-2-ylsulfanyl)-5-methoxyaniline结构式

2-(1H-imidazol-...

3-硝基-4-氯苯甲醚结构式

3-硝基-4-氯苯甲醚

~%

2-(1H-imidazol-2-ylsulfanyl)-5-methoxyaniline结构式

2-(1H-imidazol-...

5-methyl-2-(2-nitrophenyl)sulfanyl-1H-imidazole结构式

5-methyl-2-(2-n...

~87%

2-[(5-methyl-1H-imidazol-2-yl)sulfanyl]aniline结构式

2-[(5-methyl-1H...

邻氯硝基苯结构式

邻氯硝基苯

~%

2-[(5-methyl-1H-imidazol-2-yl)sulfanyl]aniline结构式

2-[(5-methyl-1H...

2-巯基咪唑结构式

2,5-二氯硝基苯结构式

2,5-二氯硝基苯

~78%

2-(4-chloro-2-nitrophenyl)sulfanyl-1H-imidazole结构式

2-(4-chloro-2-n...

2,5-二氟硝基苯结构式

2,5-二氟硝基苯

2-巯基咪唑结构式

~84%

2-(4-fluoro-2-nitrophenyl)sulfanyl-1H-imidazole结构式

2-(4-fluoro-2-n...

2-巯基咪唑结构式

4-氯-3-硝基三氟甲苯结构式

4-氯-3-硝基三氟甲苯

~93%

2-[2-nitro-4-(trifluoromethyl)phenyl]sulfanyl-1H-imidazole结构式

2-[2-nitro-4-(t...

2-巯基咪唑结构式

3-硝基-4-氯苯甲醚结构式

3-硝基-4-氯苯甲醚

~69%

2-(4-methoxy-2-nitrophenyl)sulfanyl-1H-imidazole结构式

2-(4-methoxy-2-...