Templating effects in aristolochene synthase catalysis: elimination versus cyclisation

…, V González, M Senske, RK Allemann

文献索引：Faraldos, Juan A.; Gonzalez, Veronica; Senske, Michael; Allemann, Rudolf K. Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 6920 - 6923

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被引用次数: 10

摘要

Analysis of the products generated by mutants of aristolochene synthase from P. roqueforti (PR-AS) revealed the prominent structural role played by the aliphatic residue Leu 108 in maintaining the productive conformation of farnesyl diphosphate to ensure C1–C10 (σ- bond) ring-closure and hence (+)-aristolochene production.