Reductive cleavage of hydroxylamine derivatives by dihydrolipoic acid-iron (II)

…, M Kijima, T Endo, M Okawara

文献索引：Nambu, Yoko; Kijima, Masashi; Endo, Takeshi; Okawara, Makoto Journal of Organic Chemistry, 1982 , vol. 47, # 16 p. 3066 - 3069

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被引用次数: 18

摘要

The reduction of hydroxylamine derivatives was attempted with dihydrolipoic acid-iron (I1) to obtain cor-responding alcohols and amines in high yields under a mild condition (pH 9.1, 30" C). Some dithiols other than dihydrolipoic acid which cyclize to form disulfides were also useful for the reduction, and ferrous ion worked as an effective catalyst. From the spectroscopic and kinetic studies, the reduction was found to proceed through 1: 1: 1 ...