Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity

AI Khalaf, RD Waigh, AJ Drummond…

文献索引：Knight, David W.; Nott, Andrew P. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 791 - 794

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被引用次数: 55

摘要

... Journal of Medicinal ... For example, the replacement of an imidazole by a thiazole would be expected to increase log P by at least one unit. 9 This argument led us to consider further that distamycin and netropsin, through their methyl groups, do not take full advantage of the ...