Inhibition of nitric oxide production by the carbazole compound LCY-2-CHO via blockade of activator protein-1 and CCAAT/enhancer-binding protein activation in …

…, CJ Chen, LJ Huang, SC Kuo, RH Lin, JP Wang

文献索引：Chang, Ling-Chu; Tsao, Lo-Ti; Chang, Chi-Sen; Chen, Chun-Jung; Huang, Li-Jiau; Kuo, Sheng-Chu; Lin, Ruey-Hseng; Wang, Jih-Pyang Biochemical Pharmacology, 2008 , vol. 76, # 4 p. 507 - 519

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被引用次数: 33

摘要

Excessive nitric oxide (NO) production by activated microglia plays a critical role in neurodegenerative disorders. In this study, we found that 9-(2-chlorobenyl)-9H-carbazole-3- carbaldehyde (LCY-2-CHO) suppressed the NO production in lipopolysaccharide (LPS)/interferon-γ (IFNγ)-stimulated murine microglial N9 and BV-2 cells and in LPS- stimulated N9 cells and rat primary microglia. LCY-2-CHO had no cytotoxic effect on ...