前往化源商城

Inhibition of human leukocyte elastase by functionalized N-aryl azetidin-2-ones: substituent effects at C-3 and benzylic positions

…, R Kobaiter, R Joyeau, M Wakselman

文献索引:Zrihen; Labia; Wakselman European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314

全文:HTML全文

被引用次数: 26

摘要

A series of functionalized N-aryl azetidin-2-ones with a latent alkylating group was prepared by a flexible four-step synthesis. They met criteria expected for a suicide-type inactivation of human leukocyte elastase (HLE) and porcine pancreatic elastase (PPE), with no inactivation

 相关合成线路

~35%

~%

~82%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~84%

~%

~%

~%

~%

~64%

~%

~32%

~%

~53%

~%

~%

~%

~48%

~%

~%

~%

~%

~%

~%

~%

~66%

~%

~%

~%

~94%

~%

~%

~67%

~%

~%

~64%

~%

~%

~%

~88%

~%

~%

~%

~%

~%

~%

~%

~%

~38%

~51%

~%

~81%

~%

~%

~86%

~%

~%

~40%

~%

~%

~%

~99%

~%

~%

~%

~78%

~%

~%

~80%

~%

~%

~%

~%

~71%

~%

~79%

~%

~%

~%

~78%

~%

~%

~%

~%

~90%

~60%

~%

~76%

~60%

~%

~34%

~%

~%

~45%

~%

~%

~%

~%

~%

~20%

~%

~%

~%

~%

~%

~80%

~%

~25%

~%

~%

~%

~60%

~%

~%

~58%

~%

~%

~%

~49%

~%

~%

~%

~%

~%

~%

~68%

~75%

~%

~49%

~%

~92%

~%

~%

~77%

~%

~%

~%

~%