New antiarrhythmic agents. N-aryl-8-pyrrolizidinealkanamides

S Miyano, K Sumoto, F Satoh, K Shima…

文献索引：Miyano, Seiji; Sumoto, Kunihiro; Satoh, Fumio; Shima, Keiyu; Hayashimatsu, Mariko; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 714 - 717

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被引用次数: 34

摘要

The synthesis and antiarrhythmic activity of N-aryl-8-pyrrolizidinealkanamides are described. The target compounds were evaluated for their ability to protect against chloroform-induced fibrillation in mice. Many of them were found to have antifibrillatory activity comparable to that of lidocaine; several are more potent than lidocaine. N-(2, 6- Dimethylphenyl)-8-pyrroliiidineacetamide (64, which was found to be more potent and ...