Tetrahedron

The preparation of functionalized amines and amides using benzotriazole derivatives and organozinc reagents

AR Katritzky, S Strah, SA Belyakov

文献索引：Katritzky, Alan R.; Strah, Sonja; Belyakov, Sergei A. Tetrahedron, 1998 , vol. 54, # 25 p. 7167 - 7178

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被引用次数: 29

摘要

Secondary and tertiary amines 6 are conveniently prepared in good yields by reacting organozinc halides with adducts 4, which are derived from the corresponding amines, aldehydes and benzotriazole. The use of organozinc reagents enables the introduction of nitro, cyano or ester functionalities into amine mainframes. This methodology was also used to prepare functionalized amides 8.