Stereoselective total synthesis of the potent anti-asthmatic compound CMI-977 (LDP-977)

LC Dias, LS Farina, MAB Ferreira

文献索引：Dias, Luiz Carlos; Farina, Lui Strambi; Ferreira, Marco Antonio Barbosa Journal of the Brazilian Chemical Society, 2013 , vol. 24, # 2 p. 184 - 190

全文：HTML全文

被引用次数: 1

摘要

ABSTRACT A short and efficient stereoselective total synthesis of CMI-977 (LDP-977), a potent and orally active anti-asthmatic compound, was developed. The key steps involve a highly diastereoselective Mukaiyama oxidative cyclization, which provides the trans-THF (tetrahydrofuran) unit and a Seyferth-Gilbert homologation to construct the triple bond in the target molecule. The synthesis of the key chiral building block was performed using ...