Quinoline-3-carbothioamides and related compounds as novel immunomodulating agents

…, H Nishimura, T Ogino, N Seki, A Sugiyama…

文献索引：Tojo, Takashi; Spears, Glen W; Tsuji, Kiyoshi; Nishimura, Hiroaki; Ogino, Takashi; Seki, Nobuo; Sugiyama, Aiko; Matsuo, Masaaki Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 17 p. 2427 - 2430

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被引用次数: 17

摘要

A series of quinoline-3-carbothioamides and their analogues was prepared via four synthetic routes and evaluated for their antinephritic and immunomodulating activities. The optimal compound 9g strongly inhibited the T-cell independent antibody production in mice immunized with TNP-LPS and was highly effective in two nephritis models, namely chronic graft-versus-host disease and autoimmune MRL/l mice.