Inhibitory effects of substituted cinnamic acid esters on mushroom tyrosinase

Z Zhang, J Liu, F Wu, L Zhao

文献索引：Zhang, Zhenghua; Liu, Jinbing; Wu, Fengyan; Zhao, Liangzhong Letters in Drug Design and Discovery, 2013 , vol. 10, # 6 p. 529 - 534

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被引用次数: 2

摘要

A series of substituted cinnamic acid esters were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. Compound 8 was found to be the most potent inhibitor with IC50 value of 5.60 µM. Preliminary structure activity relationships (SARs) were concluded. The inhibition kinetics analyzed by Lineweaver–Burk plots revealed that compound 8 was anti-competitive inhibitor.