Palladium??catalyzed allylation of α??hydroxy acids

H Moorlag, JG de Vries, B Kaptein…

文献索引：Moorlag, Henk; Vries, Johannes G. de; Kaptein, Bernard; Schoemaker, Hans E.; Kamphuis, Johan; Kellogg, Richard M. Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, # 3 p. 129 - 137

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被引用次数: 17

摘要

Abstract Mandelic and lactic acids are converted to the 1, 3-dioxolan-4-ones by treatment with acetone dimethyl acetal. Deprotonation followed by treatment with an allyl acetate and a catalytic amount (1 mol%) of palladium catalyst afforded the allylated dioxolanones, which could be hydrolyzed to the corresponding α-allyl α-hydroxy acids. The lithium enolate of the dioxolanone of mandelic acid was also coupled with methallyl, cinnamyl, geranyl and (E)- ...