Journal of the American Chemical Society

Activity-based probes that target functional subclasses of phospholipases in proteomes

SE Tully, BF Cravatt

文献索引：Tully, Sarah E.; Cravatt, Benjamin F. Journal of the American Chemical Society, 2010 , vol. 132, p. 3264 - 3265

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被引用次数: 34

摘要

Phospholipases are a large and diverse set of enzymes that metabolize the phospholipid components of cell membranes and function in key lipid-signaling pathways. The molecular characterization of novel phospholipases would benefit from chemical probes that selectively target these enzymes on the basis of their distinct substrate specificities and catalytic properties. Here we present the synthesis and characterization of a set of activity- ...