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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

General method for the synthesis of selectively N-alkylated polyamines

…, MJ Payne, MA Balk, JL Gress, FD Harris…

文献索引：Nordlander, J. Eric; Payne, Mark J.; Balk, Michael A.; Gress, Julia L.; Harris, Frederick D.; et al. Journal of Organic Chemistry, 1984 , vol. 49, p. 133 - 138

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被引用次数: 25

摘要

A versatile method is presented for the synthesis of linear polyamines-in particular, the naturally ubiquitous putrescine, spermidine, and spermine-regiospecifically N-alkylated or N- polyalkylated. The new approach is based on the acylation of amines with N-(trifluoroacety1) amino acid chlorides, optional alkylation followed by selective saponification of the (trifluoroacetylhnino function, analogous reacylation, and polyamide to polyamine ...

3-(三氟乙酰氨基)丙酸结构式

3-(三氟乙酰氨基)丙酸

~%

N-benzyl-3-[(2,2,2-trifluoroacetyl)amino]propanamide结构式

N-benzyl-3-[(2,...

N-trifluoroacetyl-β-alanyl chloride结构式

N-trifluoroacet...

苄胺结构式

~%

N-benzyl-3-[(2,2,2-trifluoroacetyl)amino]propanamide结构式

N-benzyl-3-[(2,...

六氢吡啶结构式

N-(Trifluoroacetyl)-γ-aminobutyric Acid Chloride结构式

N-(Trifluoroace...

~%

2,2,2-trifluoro-N-(4-oxo-4-piperidin-1-ylbutyl)acetamide结构式

2,2,2-trifluoro...

N-(Trifluoroacetyl)-γ-aminobutyric Acid Chloride结构式

N-(Trifluoroace...

N-乙基苯胺结构式

~%

N-ethyl-N-phenyl-4-[(2,2,2-trifluoroacetyl)amino]butanamide结构式

N-ethyl-N-pheny...

N-(Trifluoroacetyl)-γ-aminobutyric Acid Chloride结构式

N-(Trifluoroace...

二甲胺结构式

~%

N,N-dimethyl-4-[(2,2,2-trifluoroacetyl)amino]butanamide结构式

N,N-dimethyl-4-...

N-benzyl-3-[(2,2,2-trifluoroacetyl)amino]propanamide结构式

N-benzyl-3-[(2,...

碘甲烷结构式

~65%

N-benzyl-3-[methyl-(2,2,2-trifluoroacetyl)amino]propanamide结构式

N-benzyl-3-[met...

3-(三氟乙酰氨基)丙酸结构式

3-(三氟乙酰氨基)丙酸

~%

N-benzyl-3-[methyl-(2,2,2-trifluoroacetyl)amino]propanamide结构式

N-benzyl-3-[met...

N-trifluoroacetyl-β-alanyl chloride结构式

N-trifluoroacet...

~%

N-benzyl-3-[methyl-(2,2,2-trifluoroacetyl)amino]propanamide结构式

N-benzyl-3-[met...

N-benzyl-2,2,2-trifluoro-N-(2-morpholino-2-oxoethyl)acetamide结构式

N-benzyl-2,2,2-...

~51%

2-(benzylamino)-1-morpholin-4-ylethanone结构式

2-(benzylamino)...

2,2,2-trifluoro-N-(2-morpholin-4-yl-2-oxoethyl)acetamide结构式

2,2,2-trifluoro...

~%

2-(benzylamino)-1-morpholin-4-ylethanone结构式

2-(benzylamino)...

N-benzyl-3-[methyl-(2,2,2-trifluoroacetyl)amino]propanamide结构式

N-benzyl-3-[met...

~88%

N-benzyl-3-(methylamino)propanamide结构式

N-benzyl-3-(met...

N-benzyl-3-[(2,2,2-trifluoroacetyl)amino]propanamide结构式

N-benzyl-3-[(2,...

~%

N-benzyl-3-(methylamino)propanamide结构式

N-benzyl-3-(met...

2,2,2-trifluoro-N-(4-oxo-4-piperidin-1-ylbutyl)acetamide结构式

2,2,2-trifluoro...

~51%

4-amino-1-piperidin-1-ylbutan-1-one结构式

4-amino-1-piper...

六氢吡啶结构式

~%

4-amino-1-piperidin-1-ylbutan-1-one结构式

4-amino-1-piper...

2,2,2-trifluoro-N-(2-morpholin-4-yl-2-oxoethyl)acetamide结构式

2,2,2-trifluoro...

~%

N-苄基-N-2-(4-吗啉)乙胺2盐酸盐结构式

N-苄基-N-2-(4-吗啉)...

N-benzyl-2,2,2-trifluoro-N-(2-morpholino-2-oxoethyl)acetamide结构式

N-benzyl-2,2,2-...

~%

N-苄基-N-2-(4-吗啉)乙胺2盐酸盐结构式

N-苄基-N-2-(4-吗啉)...

2-(benzylamino)-1-morpholin-4-ylethanone结构式

2-(benzylamino)...

~%

N-苄基-N-2-(4-吗啉)乙胺2盐酸盐结构式

N-苄基-N-2-(4-吗啉)...

吗啉结构式

(2,2,2-Trifluoro-acetylamino)-acetyl chloride结构式

(2,2,2-Trifluor...

~%

2,2,2-trifluoro-N-(2-morpholin-4-yl-2-oxoethyl)acetamide结构式

2,2,2-trifluoro...

N,N-dimethyl-4-[(2,2,2-trifluoroacetyl)amino]butanamide结构式

N,N-dimethyl-4-...

~%

4-氨基-N,N-二甲基丁酰胺结构式

4-氨基-N,N-二甲基丁酰胺

4-氨基-N,N-二甲基丁酰胺结构式

4-氨基-N,N-二甲基丁酰胺

~%

N-[3-[[4-(dimethylamino)-4-oxobutyl]amino]-3-oxopropyl]benzamide结构式

N-[3-[[4-(dimet...

N,N-dimethyl-4-[(2,2,2-trifluoroacetyl)amino]butanamide结构式

N,N-dimethyl-4-...

~%

N-[3-[[4-(dimethylamino)-4-oxobutyl]amino]-3-oxopropyl]benzamide结构式

N-[3-[[4-(dimet...

N,N-dimethyl-4-(3-(2,2,2-trifluoroacetamido)propanamido)butanamide结构式

N,N-dimethyl-4-...

~%

N-[3-[[4-(dimethylamino)-4-oxobutyl]amino]-3-oxopropyl]benzamide结构式

N-[3-[[4-(dimet...