Mechanistic aspects of hydrogen addition during enantioselective rhodium-catalysed reduction of C [double bond, length as m-dash] C double bonds with formic acid/ …

S Lange, W Leitner

文献索引：Lange, Susanne; Leitner, Walter Dalton Transactions, 2002 , # 5 p. 752 - 758

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被引用次数: 11

摘要

Deuterium labelling experiments reveal a remarkably different hydrogen addition mode during homogeneously catalysed CC bond reduction of itaconic acid derivatives 1a–d using molecular hydrogen (hydrogenation) or formic acid/triethylamine (transfer hydrogenation). The expected vicinal addition of two hydrogen atoms across the double bond prevails for all substrates in conventional hydrogenation, whereas the deuterium pattern depends largely ...