Novel oxazolidinone–quinolone hybrid antimicrobials

MF Gordeev, C Hackbarth, MR Barbachyn…

文献索引：Gordeev, Mikhail F.; Hackbarth, Corinne; Barbachyn, Michael R.; Banitt, Lee S.; Gage, James R.; Luehr, Gary W.; Gomez, Marcela; Trias, Joaquim; Morin, Sara E.; Zurenko, Gary E.; Parker, Christian N.; Evans, Jonathan M.; White, Richard J.; Patel, Dinesh V. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4213 - 4216

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被引用次数: 54

摘要

Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogues 2, 5, and 6 display an improved potency versus linezolid against gram-positive and fastidious gram- negative pathogens. The compounds are also active against linezolid-and ciprofloxacin- resistant Staphylococcus aureus and Enterococcus faecium strains. The MOA for these ...