Evaluation of Re and 99mTc complexes of 2-(4′-aminophenyl) benzothiazole as potential breast cancer radiopharmaceuticals

…, M Sagnou, M Paravatou-Petsotas…

文献索引：Tzanopoulou, Stamatia; Sagnou, Marina; Paravatou-Petsotas, Maria; Gourni, Eleni; Loudos, George; Xanthopoulos, Stavros; Lafkas, Daniel; Kiaris, Hippokratis; Varvarigou, Alexandra; Pirmettis, Ioannis C.; Papadopoulos, Minas; Pelecanou, Maria Journal of Medicinal Chemistry, 2010 , vol. 53, # 12 p. 4633 - 4641

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被引用次数: 53

摘要

The synthesis of M (I)(CO) 3 (NNO)(M= Re, 99mTc) complexes conjugated to the antitumor agent 2-(4′-aminophenyl) benzothiazole and to its 6-methyl derivative, as well as their in vitro and in vivo biological evaluation as breast cancer radiopharmaceuticals, is reported. The Re complexes displayed under the fluorescence microscope clear uptake by the sensitive to the 2-(4′-aminophenyl) benzothiazole pharmacophore breast cancer cell ...