6-Substituted 1H-quinolin-2-ones and 2-methoxy-quinolines: synthesis and evaluation as inhibitors of steroid 5α reductases types 1 and 2

E Baston, A Palusczak, RW Hartmann

文献索引：European Journal of Medicinal Chemistry, , vol. 35, # 10 p. 931 - 940

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被引用次数: 54

摘要

... European Journal of Medicinal Chemistry. ... Yield: 81 %, pale yellow needles, mp: 165–166 °C. 1 H-NMR: δ 1.27 (t; 3H, 3 J=7.08 Hz, CH 2 ); 3.95 (q; 2H, 3 J=7.08 Hz, CH 3 ); 5.50 (d; 1H, 3 J=12.40 Hz, O CH); 7.49 (d; 1H, 3 J=12.40 Hz, OCH ); 7.46 u. 7.58 (AA′BB′; 4H ...