Bioorganic & medicinal chemistry letters

Synthesis and antihyperglycemic evaluation of various protoberberine derivatives

X Bian, L He, G Yang

文献索引：Bian, Xiaoli; He, Langchong; Yang, Guangde Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1380 - 1383

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被引用次数: 39

摘要

Various berberine derivatives (2–17) were synthesized and their antihyperglycemic activities were evaluated in a model of β-cell-membrane chromatography and a model of alloxan- induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure–activity relationships were discussed.