Chemistry Letters

Highly Efficient and Enantioselective Method for the Synthesis of Chiral Building Blocks Derived from meso-1, 3-Propanediols.

T Oriyama, H Taguchi, D Terakado, T Sano

文献索引：Oriyama, Takeshi; Taguchi, Hiromoto; Terakado, Dai; Sano, Tomohumi Chemistry Letters, 2002 , # 1 p. 26 - 27

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被引用次数: 22

摘要

Highly efficient, direct, and enantioselective synthesis of useful chiral building blocks with excellent ee was performed by the catalytic asymmetric acylation of meso-1, 3-propanediols. A structurally most simple meso-1, 3-propanediol, 2-methyl-1, 3-propanediol, was asymmetrized in 96% ee catalyzed by 0.5 mol% of chiral 1, 2-diamine.