Synthesis and structure-activity studies in a series of 7. alpha.-halogeno corticosteroids

…, J Berkenkoph, M Monahan, X Fernandez…

文献索引：Shue; Green; Berkenkoph; Monahan; Fernandez; Lutsky Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 430 - 437

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被引用次数: 11

摘要

The preparation and topical antiinflammatory potencies of a series of'in-halogeno-16- substituted-prednisolone derivatives are described. The 7a-Chl0rO, 7aLu-bromo, and 7a- iodo corticosteroids were obtained by addition of hydrogen halide to the 6, 7-dehydro compounds. The extent of addition of HCl varied with substitution at C-11, while no addition of HF was observed at all. The 7n-flUOro corticosteroids were prepared by reaction of the ...