Synthesis and biological evaluation of a triazole-based library of pyrido [2, 3-d] pyrimidines as FGFR3 tyrosine kinase inhibitors

L Le Corre, AL Girard, J Aubertin, F Radvanyi…

文献索引：Organic and Biomolecular Chemistry, , vol. 8, # 9 p. 2164 - 2173

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被引用次数: 25

摘要

... Results and discussion. Chemical Synthesis. Our aim was to build a library of triazole-based inhibitors through efficient click-chemistry connection between the core structure of PD173074 and various substituents. ... (e) NaH, tBuNCO, DMF, 0 °C, 8 h then rt, 16 h, 90%. ...